Free clinical pharmacology MCQ exam model for clinical students

Explanation:

• Drug–drug interaction → Correct because polypharmacy commonly alters drug levels.

• Genetic variation → Incorrect because it explains variability but is less common.

• Drug allergy → Incorrect because it is immune-mediated and less frequent.

• Drug overdose → Incorrect because it is avoidable and less common.

• Idiosyncratic reaction → Incorrect because it is rare and unpredictable.

Explanation:

• Rapidly achieve therapeutic concentration → Correct because loading dose compensates for long half-life.

• Maintain steady-state concentration → Incorrect because this is the role of maintenance dose.

• Reduce adverse effects → Incorrect because loading dose may increase side effects.

• Prolong drug action → Incorrect because it affects onset, not duration.

• Improve bioavailability → Incorrect because bioavailability depends on formulation and route.

Explanation:

• Liver → Correct because portal circulation exposes drugs to hepatic enzymes.

• Kidney → Incorrect because it is involved in excretion.

• Lung → Incorrect because it plays minor metabolic role.

• Heart → Incorrect because it has no metabolic role.

• Brain → Incorrect because it is protected by blood–brain barrier.

Explanation:

• Safety → Correct because therapeutic index compares toxic dose to effective dose.

• Potency → Incorrect because it refers to dose required for effect.

• Efficacy → Incorrect because it refers to maximal effect.

• Duration of action → Incorrect because it relates to half-life.

• Bioavailability → Incorrect because it measures absorption.

Explanation:

• Renal function → Correct because kidneys are major route of drug elimination.

• Age → Incorrect because it influences clearance indirectly.

• Body weight → Incorrect because it affects volume of distribution.

• Plasma protein binding → Incorrect because it affects free drug, not clearance directly.

• Route of administration → Incorrect because it affects absorption.

Explanation:

• Stop the drug immediately → Correct because patient safety is the priority.

• Continue the drug → Incorrect because it may worsen the reaction.

• Reduce the dose only → Incorrect because serious reactions require cessation.

• Add another drug → Incorrect because it may increase interactions.

• Ignore the reaction → Incorrect because it endangers the patient.

Explanation:

• Use of drugs in humans → Correct because clinical pharmacology focuses on therapeutic use, efficacy, and safety in patients.

• Drug discovery → Incorrect because this is experimental pharmacology.

• Drug action in laboratory animals → Incorrect because this is preclinical pharmacology.

• Drug manufacturing → Incorrect because this is pharmaceutical science.

• Drug marketing → Incorrect because this is pharmaceutical management.

Explanation:

• Fraction of administered dose reaching systemic circulation → Correct because it measures extent of absorption.

• Rate of drug elimination → Incorrect because it relates to clearance.

• Drug potency → Incorrect because it refers to dose required for effect.

• Drug half-life → Incorrect because it reflects duration of action.

• Drug–protein binding → Incorrect because it affects distribution.

Explanation:

• Half-life → Correct because it determines duration of drug action and dosing frequency.

• Bioavailability → Incorrect because it affects dose size.

• Clearance → Incorrect because it affects maintenance dose.

• Volume of distribution → Incorrect because it affects loading dose.

• Potency → Incorrect because it relates to dose–response.

Explanation:

• What the body does to drugs → Correct because it includes absorption, distribution, metabolism, and excretion.

• What drugs do to the body → Incorrect because this is pharmacodynamics.

• Drug–receptor interaction → Incorrect because it is pharmacodynamics.

• Drug toxicity → Incorrect because this is toxicology.

• Drug efficacy → Incorrect because it relates to therapeutic effect.